Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21
Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson, Dana Silvian, Eric F. Zaniewski, Robert Morris, Wilhelm Haas, Lindy E. Barrett
This study identifies aberrant chromatin remodeling in Trisomy 21 NPCs that impairs neurogenesis and shows that PRC2 inhibition can partially restore neurogenic potential.
bioRxiv · Jun 3, 2026 · PreprintNeuroscience