Wilhelm Haas

This study identifies aberrant chromatin remodeling in Trisomy 21 NPCs that impairs neurogenesis and shows that PRC2 inhibition can partially restore neurogenic potential.

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.

The paper analyzes the multiome of Diversity Outbred mice to explore how aging and lifespan are related, finding that proteomic changes correlate with biological age rather than chronological age.

The paper shows that therapy-induced stress increases METTL3 translation, altering gene expression to promote tumor survival.

The paper identifies LTR5_Hs viral proteins and virus-like particles in hPGCLCs, showing their activation during early germ cell development and suppression upon gonadal anlagen settlement.

The paper shows FXR1 alters ribosomes in quiescent leukemic cells, inducing stress signals to enable non-canonical translation for chemosurvival.

This study shows that E2F inactivation in fat body cells causes systemic metabolic changes, including reduced trehalose and fat storage, which can be rescued by sugar supplementation.

The paper uses multiplexed proteomics to identify synaptic factors linked to cognitive resilience in Alzheimer's Disease by analyzing brain tissue from individuals with varying pathology and cognitive outcomes.

This study uses quantitative proteomics to analyze protein expression changes across life phases of Daphnia pulex, revealing functional shifts in response to environmental stress.

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.