Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice
Piplu Bhuiyan, Wenjia Zhang, Ge Liang, Bailin Jiang, Robert Vera, Rebecca Chae, Kyulee Kim, Lauren St. Louis, Ying Wang, Jia Liu, De‐Maw Chuang, Huafeng Wei
This study shows that intranasal lithium salt delivery in RFV reduces brain inflammation and pyroptosis, improves memory and depression-like behaviors in 5XFAD mice, with minimal side effects.
Journal of Neuroimmune Pharmacology · Mar 17, 2025Peer-reviewedNeuroscience