Author

Rongmei Chen

Chinese Academy of Sciences

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Cell Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1

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Guanghou ShuiiD· 1 shared Jianyong HuangiD· 1 shared Jing WangiD· 1 shared Kangmin HeiD· 1 shared Liu Suling· 1 shared Pei HuangiD· 1 shared Pengyu Sun· 1 shared Piyu Wu· 1 shared

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1 paper

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Cell BiologyMolecular CellPeer-reviewedNov 1, 2024

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

Jing Wang, Zhengyang An, Zhongsheng Wu…·Kangmin He

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

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humanexperimental assay

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