NeurosciencebioRxivPreprint
Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation
Mathias Kaas Ollendorff, Nicolas Chofflet, Deniz Bicer…·Simon Glerup
The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.
DOI 10.1101/2025.02.16.638491