NeurosciencebioRxivPreprint
LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formation.
Richard M. Lucas, Claudia S. Bauer, Kavitha Chinnaiya…·Kurt J. De Vos
This study identifies HDAC6 as a novel LRRK2 substrate and shows that LRRK2-mediated phosphorylation of HDAC6 enhances aggresome formation, linking LRRK2 dysfunction to Parkinson's disease pathology.
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