The gut microbiota is a determinant of sexual dimorphism in ALS-linked TDP43 mice
Evandro José Beraldi, Suk‐young Lee, Yulan Jiang, Isabel M. Rea, Rushda Phull, Catherine M. Keenan, Matthew Stephens, Martin Bardhi, Oluwamolakun O. Bankole, Gerald Pfeffer, Jeff A. Biernaskie, Kathy D. McCoy, Eran Elinav, Keith A. Sharkey, Minh Dang Nguyen
This study shows that the gut microbiota influences sexual dimorphism in ALS-linked TDP43 mice by affecting disease onset and severity, independent of sex hormones.
bioRxiv · Aug 29, 2024 · PreprintPhysiology