BioengineeringbioRxivPreprint
Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.
W. Y. Aw, C. Cho, H. Wang…·W. J. Polacheck
The paper develops a microfluidic model of PIK3CA-driven vascular malformations and identifies dysregulated Rac1/PAK and mTORC1/2 signaling as key factors in lesion formation.
DOI 10.1101/2022.09.03.506415