Structural Basis of HIV-1 Maturation Inhibitor Binding and Activity
S. Sarkar, K. K. Zadrozny, R. Zadorozhnyi, R. W. Russell, C. M. Quinn, A. Kleinpeter, S. Ablan, C. Xu, J. R. Perilla, E. O. Freed, B. K. Ganser-Pornillos, O. Pornillos, A. M. Gronenborn, T. Polenova
This study determines the structural basis of HIV-1 maturation inhibitor binding and resistance using NMR, revealing an allosteric mechanism and conformational changes in SP1 variants.
Nature Communications · Mar 4, 2023Peer-reviewedBiophysics