Evolutionary BiologybioRxiv
Purifying selection on noncoding deletions of human regulatory elements detected using their cellular pleiotropy
D. W. Radke, J. H. Sul, D. J. Balick…·S. R. Sunyaev
The paper uses genomic deletions to assess purifying selection on noncoding regulatory elements, finding preservation of DHS and enhancer sites but not transcribed or heterochromatin regions.
DOI 10.1101/gr.275263.121