Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice
I. Russo, W. Dun, S. Mehta, S. Amed, C. Tzimas, N. Fukuma, E. J. Tsai
This study shows male mice with pulmonary artery banding develop severe right ventricular dysfunction and failure due to ECM instability and chronic inflammation, while females show more adaptive remodeling without these features.
bioRxiv · Apr 3, 2024Physiology