S. Mehta

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice

This study shows male mice with pulmonary artery banding develop severe right ventricular dysfunction and failure due to ECM instability and chronic inflammation, while females show more adaptive remodeling without these features.

Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC

The paper introduces a sensitive fluorescent biosensor, ExRai-CKAR2, to study subcellular PKC activity and finds differential regulation of PKC isoforms at the ER, lysosomes, and Par complexes.

Light-gated Integrator for Highlighting Kinase Activity in Living Cells

This paper introduces KINACT, a light-gated tool that converts kinase activity into permanent fluorescent marks for analyzing kinase dynamics and signaling mechanisms.

Far-red chemigenetic biosensors for multi-dimensional and super-resolved kinase activity imaging

The paper introduces far-red chemigenetic kinase activity biosensors enabling five-color multiplexing, 4D imaging, and super-resolution via STED microscopy.

Molecular Determinants and Signaling Effects of PKA RIα Phase Separation

This study identifies molecular determinants of PKA RIα phase separation and shows how it regulates cAMP compartmentation and PKA-C spatial restriction.

Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

This study shows that quisinostat, a selective HDAC1/2 inhibitor, is brain-penetrant and enhances radiation therapy efficacy in glioblastoma models.

Machine Learning Classification of Alzheimer's Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

Psidium guajava derived carbon nanoparticles: A promising red emissive cellular bioimaging agent

This study synthesizes red-emitting carbon nanoparticles from guava leaves and demonstrates their biocompatibility and potential for bioimaging applications.

Metaproteomic analysis of nasopharyngeal swab samples to identify microbial peptides and potential co-infection status in COVID-19 patients

This study uses metaproteomic analysis of nasopharyngeal swabs to identify microbial peptides and co-infections in COVID-19 patients, revealing potential pathogens and upregulated species in severe cases.

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

TP53 knockout in MCF7 breast cancer cells induces sensitivity to fluoropyrimidine drugs.

This study shows TP53 knockout in breast cancer cells increases sensitivity to fluoropyrimidine drugs like F10, with DNA incorporation as a key mechanism.

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

This study identifies Sox2 as a key node regulated by opposing TGF-β superfamily signals, impacting anoikis resistance and metastasis in ovarian cancer.

The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice

Chronic JUUL aerosol inhalation in mice alters inflammatory states in brain, lung, heart, and colon, with flavor-dependent effects and potential long-term health risks.

Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples

This study identifies prognostic markers and therapeutic targets for COVID-19 by analyzing Omics data from nasal and BALF samples, finding S100 family genes and TXN as key factors, and validating Auranofin as a potential treatment.

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

Critical role for cold shock protein YB-1 in cytokinesis

This study identifies YB-1's role in cytokinesis by showing its necessity for microtubule organization and phosphorylation-dependent function.

Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

The paper shows that spatially distinct cAMP oscillations, in-phase with Ca2+ and out-of-phase with PKA, regulate signaling in pancreatic β cells through nanodomain clustering of adenylyl cyclases and phosphodiesterases.

Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIV

The paper uses scRNA-seq on cerebrospinal fluid from HIV patients to identify a rare microglia-like cell type associated with CNS immune activation.

Global landscape of mouse and human cytokine transcriptional regulation

The paper compiles a database of TF-cytokine gene interactions in human and mouse, identifies general principles of cytokine regulation, and highlights their relevance to immune phenotypes and diseases.

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

This study fine-maps genetic loci associated with spontaneous clearance of hepatitis C virus infection, identifying a narrower region in the MHC locus and suggesting subtype-specific effects.