A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo.
S. Morsli, C. Henriques, P. s. Ellis, H. J. Mortiboys, S. Baxendale, C. A. Loynes, S. Renshaw, I. Bellantuono
This paper develops a zebrafish model expressing p21-GFP to study senescence and test senolytics, showing that quercetin and dasatinib reduce senescent cells in a 5-day assay.
bioRxiv · Sep 19, 2022Pharmacology & Toxicology