Author

S. Renshaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Microbiology· 2 Cell Biology· 1 Evolutionary Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Organism:zebrafish· 7 Research Focus:host-pathogen & immune response· 4 Assay:imaging· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

C. A. Loynes· 3 shared L. Prince· 3 shared A. Bernut· 2 shared R. J. Evans· 2 shared S. Johnston· 2 shared A. A. R. Thompson· 1 shared A. Bojarczuk· 1 shared A. J. Cadby· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

C. A. Loynes

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis

S. A. Leon-Icaza, M. Fretaud, S. Cornelie, C. Bureau, L. Yatime, A. R. Floto, S. Renshaw, J.-L. Herrmann, C. Langevin, C. Cougoule, A. Bernut

This study shows curcumin improves inflammation and tissue damage in cystic fibrosis by restoring NRF2 activity in zebrafish and patient-derived airway organoids.

bioRxiv · Mar 17, 2024Immunology

Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes

C. F. Muir, C. C. Reyes-Aldasoro, F. Ellett, T. Prajsnar, Y. X. Ho, A. Bernut, C. A. Loynes, S. Elworthy, K. A. Bowden, A. J. Cadby, L. Prince, J. S. King, A. M. Condliffe, S. Renshaw

The paper identifies pulsatile Class I PI3K activity on neutrophil phagosomes during bacterial infection, suggesting phagosomes reopen and reclose to release or restart digestion.

bioRxiv · Feb 29, 2024 · PreprintCell Biology

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection

N. R. Choudhury, L. Urwin, B. Salamaga, L. Prince, S. Renshaw, R. M. Corrigan

This study uses a zebrafish model to show that the stringent response, mediated by (p)ppGpp synthetases, is critical for S. aureus virulence and survival within host phagocytes.

bioRxiv · Jul 12, 2023 · PreprintMicrobiology

Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System

I. Jubber, D. R. Morhardt, J. Griffin, M. G. Cumberbatch, M. Glover, Y. Zheng, I. Rehman, C. A. Loynes, S. A. Hussain, S. D. Leach, S. Renshaw, V. T. Cunliffe, J. W. Catto

The paper identifies homology between zebrafish and human distal urinary tract anatomy, including a functional urinary bladder in adult zebrafish.

bioRxiv · Jan 30, 2023 · PreprintEvolutionary Biology

A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo.

S. Morsli, C. Henriques, P. s. Ellis, H. J. Mortiboys, S. Baxendale, C. A. Loynes, S. Renshaw, I. Bellantuono

This paper develops a zebrafish model expressing p21-GFP to study senescence and test senolytics, showing that quercetin and dasatinib reduce senescent cells in a 5-day assay.

bioRxiv · Sep 19, 2022Pharmacology & Toxicology

Blood vessel occlusion by Cryptococcus neoformans is a mechanism for hemorrhagic dissemination of infection

J. Gibson, A. Bojarczuk, R. J. Evans, A. Kamuyango, R. Hotham, A. K. Lagendijk, B. M. Hogan, P. W. Ingham, S. Renshaw, S. Johnston

The paper investigates how Cryptococcus neoformans causes vessel damage and dissemination in zebrafish, finding that vascular growth and stiffness increase dissemination events.

bioRxiv · Mar 17, 2020 · PreprintPathology

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

L. Prince, S. Renshaw, A. Rahman, K. M. Henry, K. Herman, A. A. R. Thompson, H. Isles, C. Tulotta, D. Sammut, J. Rougeot, N. Khoshaein, A. Reese, K. Higgins, C. Tabor, I. Sabroe, , D. Dockrell

The paper identifies ErbB kinase inhibitors as potential therapies for neutrophilic inflammation by showing they accelerate neutrophil apoptosis in multiple models.

bioRxiv · Aug 19, 2019Immunology

15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection.

R. J. Evans, K. Pline, C. Loynes, S. Needs, M. Aldrovandi, J. Tifenbach, E. Bielska, R. Rubino, C. Nicol, R. C. May, H. Krause, V. O'Donnell, S. Renshaw, S. Johnston

bioRxiv · Jan 23, 2019Microbiology