Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.
V. Vigdorovich, H. Patel, A. Watson, A. Raappana, L. Reynolds, W. Selman, S. Beeman, P. T. Edlefsen, S. H. I. Kappe, D. N. Sather
This paper shows that combining multiple pre-erythrocytic antigens with CSP enhances sterile protection against Plasmodium sporozoite infection in a mouse model.
bioRxiv · Jun 17, 2022 · PreprintImmunology