H. Patel

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Mitochondrial defects result in decreased susceptibility to echinocandins via the transcriptional regulator Pdr1 in Candida glabrata.

This study shows that mitochondrial defects increase resistance to echinocandins in Candida glabrata via Pdr1-mediated upregulation of PDR1 expression.

Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain

This study shows that non-muscle myosin 2A lacking the ACD can co-assemble with existing filaments, indicating the ACD is not required for association with established filaments.

QM/MM simulations of EFGR with afatinib reveal the role of the beta-dimethylaminomethyl substitution

The paper uses QM/MM simulations to study the reaction mechanism of afatinib with Cys797 in EGFR, revealing a Michael addition mechanism involving deprotonation and stabilization by Asp800.

Taurine/chenodeoxycholic acid ratio as a circulating biomarker of insidious vitamin B12 deficiency in humans

The paper identifies the taurine/chenodeoxycholic acid ratio as a highly accurate biomarker for detecting vitamin B12 deficiency using metabolomic profiling in human sera.

Aerobic exercise promotes PDAC vascular normalization through S1PR1 signaling in tumor endothelial cells

This study shows aerobic exercise improves PDAC vascular function and chemotherapy efficacy via S1PR1 signaling in tumor endothelial cells.

Pharmacogenomics Guided Spaceflight: the intersection between space-flown drugs and space genes

This paper creates a database of space-flown drugs and identifies spaceflight-related gene targets to advance pharmacogenomics for space missions.

In vitro cultivation techniques for modeling liver organogenesis, building assembloids, and designing synthetic tissues

This paper presents in vitro methods to model liver organogenesis, including assembloid technology and spheroid cultivation, to study morphogenesis and migration.

Mitochondrial-nuclear variation for metabolic plasticity with potential consequences for invasion success in New Zealand mud snails

The paper measures thermal plasticity of metabolic rate in invasive and native asexual lineages of snails, finding invasive lineages have reduced metabolic rates at high temperatures.

Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens

The paper identifies auto-antibodies secreted by plasma cells in PDAC against self-antigens, suggesting a link between chronic inflammation and autoimmunity.

Global gene expression of human malaria parasite liver stages throughout intrahepatocytic development

This study provides the first comprehensive gene expression profile of Plasmodium falciparum liver stages during in vivo development, revealing key metabolic and regulatory processes.

Cell dichotomous role of STING in pulmonary hypertension

This study investigates the role of STING in pulmonary hypertension, finding that STING overactivation contributes to disease while global deficiency protects against it, with distinct cellular roles in smooth muscle and myeloid cells.

Vascular Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.

This paper shows that combining multiple pre-erythrocytic antigens with CSP enhances sterile protection against Plasmodium sporozoite infection in a mouse model.

When Citizen Science meets teaching: A storified citizen science computer game to teach and contribute to genomic data analysis

This paper describes a citizen science computer game that teaches and contributes to genomic data analysis through a story mode and instructor tools.

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy

This study identifies a novel mechanism by which c-Myc induces replication stress through increased chromatin-bound cohesins in the G1 phase.

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

The paper optimises an imaging mass cytometry workflow to study TME remodelling in mouse models after KRAS G12C inhibitor treatment.

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.

Active transport of brilliant blue FCF across the Drosophila midgut and Malpighian tubule epithelia

The paper investigates whether Drosophila actively transport Brilliant blue FCF across midgut and Malpighian tubule epithelia under cold stress and finds they can mobilize the dye via an active transcellular pathway.

Sonic stimulation, and low power microwave radiation can modulate bacterial virulence towards Caenorhabditis elegans

The paper investigates whether sonic and microwave treatments can reduce bacterial virulence towards C. elegans, finding protective effects against S. marcescens and S. aureus.

Knowledge, attitudes and awareness of the human papillomavirus among health professionals in New Zealand

This study assesses HPV knowledge, attitudes, and awareness among New Zealand health professionals, finding gaps in understanding HPV's role in cancer and testing protocols.

TCR-MHC Interaction Strength Defines Trafficking and Resident Memory Status of CD8 T cells in the Brain

This study shows that TCR-MHC interaction strength determines the trafficking and resident memory status of CD8 T cells in the brain during chronic Toxoplasma gondii infection.