A. Watson

Roles of PknB and CslA in cell wall morphogenesis of Streptomyces

This study identifies PknB-dependent phosphorylation of CslA as critical for cell wall morphogenesis in Streptomyces, showing how modulating β-glucan synthesis can counteract DivIVA dysregulation.

Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization, and de novo cell types

This paper genetically engineers an endothelial niche in human kidney organoids to enhance vascularization, maturation, and the emergence of new cell types.

A comprehensive analysis of the gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs

This study analyzes gut and skin microbiota in Shiba Inu dogs with canine atopic dermatitis and evaluates the impact of JAK inhibitor treatment on microbiota composition.

Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.

This paper shows that combining multiple pre-erythrocytic antigens with CSP enhances sterile protection against Plasmodium sporozoite infection in a mouse model.

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

Peptide Antidotes to SARS-CoV-2 (COVID-19)

This paper designs and tests SARS-BLOCK peptides as antidotes to SARS-CoV-2 by inhibiting spike protein-ACE2 binding and enhancing neutralizing antibody responses.

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis.

This study identifies the mTORC1-Plin3 pathway as essential for lipophagy, which protects against hepatosteatosis by promoting lipid droplet degradation.

Viral-mediated optogenetic stimulation of peripheral motor nerves in non-human primates

This study demonstrates optogenetic stimulation of peripheral motor nerves in non-human primates using viral constructs, showing functional expression and EMG responses to light.

Speed breeding in growth chambers and glasshouses for crop breeding and model plant research

This paper presents speed breeding protocols for various crops and model plants, detailing conditions and methods to accelerate generation advancement in growth chambers and glasshouses.

Speed breeding: a powerful tool to accelerate crop research and breeding

This paper introduces speed breeding, a method that accelerates crop research and breeding by shortening generation times and enabling more generations per year.