Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical disease
J. Cao, Y. Deschambault, J. Lynch, B. Warner, K. Tierney, D. Huynh, R. Vendramelli, N. Tailor, S. Booth, B. Sajesh, K. Frost, K. LeBlanc, C. Layne, L. Lin, D. Beniac, , D. Kobasa
This study shows that a single immunization with a vaccinia virus expressing both SARS-CoV-2 spike and nucleocapsid proteins protects hamsters better than expressing either protein alone.
bioRxiv · Dec 2, 2021Microbiology