The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.
E. Klontz, J. O. Obi, Y. Wang, G. Glendening, J. Carr, C. Tsibouris, S. Buddula, S. Nallar, A. Soares, D. Beckett, J. S. Redzic, E. Eisenmesser, C. Palm, K. Schmidt, A. Scudder, , G. A. Snyder
The paper reports the crystal structure of Acinetobacter baumannii TIR domain and its NAD+ hydrolase activity, showing conformational changes and kinetic effects upon substrate binding.
bioRxiv · May 19, 2023 · PreprintBiochemistry