Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes
O. Diebold, V. Gonzalez, L. Venditti, C. Sharp, R. A. Blake, J. Stevens, S. Caddy, P. Digard, A. Borodavka, E. Gaunt
This paper tests engineering rotavirus to express SARS-CoV-2 spike epitopes, finding that inserting peptides into NSP3 is feasible while VP4 insertions impair viral replication.
bioRxiv · Mar 23, 2022 · PreprintMicrobiology