Author

C. Sharp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. Digard· 3 shared E. R. Gaunt· 2 shared F. Grey· 2 shared A. Agan· 1 shared A. Borodavka· 1 shared A. C. Rinaldi· 1 shared A. Corrales· 1 shared A. McNaughton· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

P. Digard

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

C. Sharp, B. H. Thompson, T. J. Nash, O. Lee, R. M. Pinto, L. Thorley, Y.-T. Lin, S. Sives, H. Wise, S. M. R. Clohisey, F. Grey, L. Vervelde, P. Simmonds, P. Digard, E. R. Gaunt

This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.

bioRxiv · Apr 29, 2022Microbiology

Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes

O. Diebold, V. Gonzalez, L. Venditti, C. Sharp, R. A. Blake, J. Stevens, S. Caddy, P. Digard, A. Borodavka, E. Gaunt

This paper tests engineering rotavirus to express SARS-CoV-2 spike epitopes, finding that inserting peptides into NSP3 is feasible while VP4 insertions impair viral replication.

bioRxiv · Mar 23, 2022 · PreprintMicrobiology

Towards understanding diversity, endemicity and global change vulnerability of soil fungi

L. Tedersoo, V. Mikryukov, A. Zizka, M. Bahram, N. Hagh-Doust, S. Anslan, O. Prylutskyi, M. Delgado-Baquerizo, F. T. Maestre, J. Parn, M. opik, M. Moora, M. Zobel, M. Espenberg, u. Mander, , Zahn

The paper identifies unknown soil fungi using PacBio sequencing and evaluates standardization methods to analyze global diversity, endemicity, and vulnerability patterns.

bioRxiv · Mar 17, 2022 · PreprintEcology

Bacterial competition systems share a domain required for inner membrane transport of the nuclease bacteriocin pyocin G

I. Atanaskovic, C. Sharp, C. Press, R. Kaminska, C. Kleanthous

This study identifies a conserved domain essential for inner membrane translocation of nucleases in bacterial competition systems, using PyoG as a model.

bioRxiv · Nov 17, 2021 · PreprintMicrobiology

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

P. Digard, H.-M. Lee, C. Sharp, F. Grey, E. R. Gaunt

The paper analyzes CpG dinucleotide composition in SARS-CoV-2 and other coronaviruses to understand its role in replication and cross-species transmission.

bioRxiv · May 8, 2020Evolutionary Biology

Human Herpes Virus 6 (HHV-6) - Pathogen or Passenger? A pilot study of clinical laboratory data and next generation sequencing

C. Sharp, T. Golubchik, W. F. Gregory, A. McNaughton, N. Gow, M. Selvaratnam, A. Mirea, D. Foster, M. Andersson, P. Klenerman, K. Jeffery, P. Matthews

This study examines HHV-6 prevalence in clinical samples using PCR and NGS, finding 33% positivity in hematology patients and 20% detection via NGS in CSF and respiratory samples.

bioRxiv · Jul 5, 2018 · PreprintMicrobiology