Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion
X. Guan, A. Upadhyay, R. K. Dumpati, S. Munshi, S. Roy, S. Chall, A. Rahnamoun, C. Reverdy, G. Errasti, T. Delacroix, A. Ghosh, R. Chakrabarti
This study identifies novel SIRT3 activators that restore catalytic activity under NAD+ depletion, offering potential therapeutic applications for age-related diseases.
bioRxiv · Nov 9, 2023Biochemistry