A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors
M. Parada-Kusz, A. E. Clatworthy, E. R. Goering, S. M. Blackwood, E. J. Salm, C. Choi, S. Combs, J. S. Lee, C. Rodriguez-Osorio, S. Tomita, D. T. Hung
The paper identifies 3-hydroxy-kynurenine as a tryptophan metabolite that enhances host survival during bacterial infection by modulating kainate receptors in macrophages.
bioRxiv · Aug 16, 2023Immunology