ImmunologybioRxiv
A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors
M. Parada-Kusz, A. E. Clatworthy, E. R. Goering…·D. T. Hung
The paper identifies 3-hydroxy-kynurenine as a tryptophan metabolite that enhances host survival during bacterial infection by modulating kainate receptors in macrophages.
DOI 10.1038/s41589-024-01635-z