Author

S. Curk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Saric· 3 shared G. Meisl· 3 shared S. LinseiD· 3 shared C. M. Dobson· 2 shared M. Vendruscolo· 2 shared P. Arosio· 2 shared T. C. Michaels· 2 shared A. Dear· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiophysics

A. Saric

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3 papers

Recent·Most cited

Self-replication of Abeta42 aggregates occurs on small and isolated fibril sites

S. Curk, J. Krausser, G. Meisl, D. Frenkel, S. Linse, T. C. T. Michaels, T. P. J. Knowles, A. Saric

The paper investigates A{beta}42 fibril self-replication using statistical mechanics and modeling, finding replication occurs on isolated small catalytic sites on the fibril surface.

bioRxiv · Jul 5, 2023 · PreprintBiophysics

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

T. C. Michaels, A. Saric, S. Curk, K. Bernfur, P. Arosio, G. Meisl, A. Dear, S. Cohen, M. Vendruscolo, C. M. Dobson, S. Linse, T. P. Knowles

This study investigates the dynamics of Aβ42 oligomers during amyloid fibril formation, revealing that most oligomers dissociate into monomers rather than forming fibrils.

Nature Chemistry · Apr 13, 2020Peer-reviewedBiophysics

Thermodynamic and kinetic design principles for protein aggregation inhibitors

T. C. Michaels, A. Saric, G. Meisl, G. T. Heller, S. Curk, P. Arosio, S. Linse, C. M. Dobson, M. Vendruscolo, T. Knowles

This study develops a kinetic theory to identify thermodynamic and kinetic signatures of effective protein aggregation inhibitors.

bioRxiv · Feb 22, 2020 · PreprintBiophysics