A. Saric

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

A liquid-like coat mediates chromosome clustering during mitotic exit

This study shows Ki-67 switches from repelling to attracting chromosomes during mitotic exit, forming a liquid-like coat that drives chromosome clustering through phase separation.

Elucidating the role of water in collagen self assembly by isotopically modulating collagen hydration

This study investigates how water isotopes affect collagen self-assembly by comparing D2O and H2O, finding faster assembly and thinner fibrils in D2O due to reduced hydration.

Self-replication of Abeta42 aggregates occurs on small and isolated fibril sites

The paper investigates A{beta}42 fibril self-replication using statistical mechanics and modeling, finding replication occurs on isolated small catalytic sites on the fibril surface.

Self-organisation of mortal filaments: the role of FtsZ treadmilling in bacterial division ring formation

The paper shows that FtsZ treadmilling drives nematic ordering in bacterial cells, enabling division ring formation through local dissolution of misaligned filaments.

Modelling Membrane Reshaping by Staged Polymerization of ESCRT-III Filaments

The paper models how ESCRT-III filaments reshape membranes through staged polymerization and depolymerization, identifying mechanical conditions for membrane deformation and scission.

The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division

The paper uses super-resolution microscopy and computational modeling to show how CdvB/CdvB1/CdvB2 proteins form a patterned composite ESCRT-III division ring that disassembles stepwise to drive archaeal cell division.

Mechanochemical rules for shape-shifting filaments that remodel membranes

The paper develops a kinetic model to study how composite filaments remodel membranes by sequentially changing composition, showing this process lowers the energetic barrier for membrane deformation.

Controlling cluster size in 2D phase-separating binary mixtures with specific interactions

The paper models 2D cluster formation on membranes using molecular dynamics, showing that concentrations, valence, and bond strength control cluster size and growth kinetics.

Durotaxis of passive nanoparticles on elastic membranes

This paper shows passive nanoparticles can move directionally on elastic membranes with rigidity gradients, accumulating in regions of specific mechanical properties.

Physical mechanisms of ESCRT-III-driven cell division in archaea

The paper develops a physical model to explain how ESCRT-III filaments drive cell division in archaea, showing that active geometry changes and disassembly are sufficient for efficient splitting.

Dynamics of vesicle reshaping and scission under osmotic shocks

This study uses molecular dynamics simulations to examine how osmotic shocks affect lipid vesicle morphology, revealing distinct dynamics for hypo- and hypertonic conditions.

Physical modelling of multivalent interactions in the nuclear pore complex

This study develops computational models to analyze the role of heterogeneity in FG Nups and NTRs, finding minor effects on binding equilibria but significant impacts on kinetics and multivalency.

Influence of membrane-cortex linkers on the extrusion of membrane tubes

This study investigates how membrane-cortex linkers affect membrane tube extrusion through simulations and experiments, finding non-linear force dependencies and increased stability against coalescence.

PLCγ1 promotes phase separation of the T cell signaling clusters

This study shows PLCγ1 promotes phase separation of LAT in T cell signaling by crosslinking it and protecting it from dephosphorylation, enhancing ERK and SLP76 activation.

Modelling fibrillogenesis of collagen-mimetic molecules

This paper develops a computational model to study how charged residues on collagen-mimetic molecules drive the formation of striped fibrils, showing that multi-body interactions determine the fibril pattern.

Characterising the Diffusion of Biological Nanoparticles on Fluid and Elastic Membranes

This study uses simulations to show that anomalous diffusion of nanoparticles on cell membranes is caused by receptor clustering and membrane stiffness, while normal diffusion occurs on fluid membranes.

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

This study investigates the dynamics of Aβ42 oligomers during amyloid fibril formation, revealing that most oligomers dissociate into monomers rather than forming fibrils.

Designing membrane-reshaping nanostructures through artificial evolution

This study uses artificial evolution with molecular dynamics to design ligand patterns on nanoparticles that enhance cell uptake, revealing that one-dimensional ligand chains are optimal in low-ligand regimes.

Thermodynamic and kinetic design principles for protein aggregation inhibitors

This study develops a kinetic theory to identify thermodynamic and kinetic signatures of effective protein aggregation inhibitors.

Physical mechanisms of amyloid nucleation on fluid membranes

This study identifies two distinct nucleation pathways for amyloid fibril formation on fluid membranes and quantifies how membrane properties influence these pathways.

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

This study identifies mTORC1-dependent translation as a mechanism for endo-lysosome expansion and antigen presentation during phagocyte activation.

Highlighting curcumin-induced crosstalk between autophagy and apoptosis: A biochemical approach coupling impedancemetry, imaging, and flow cytometry

This paper investigates curcumin's effects on cancer cells using biochemical methods, showing it induces ER stress, apoptosis, and autophagy with complex interactions.

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics

This study shows FG nups in the nuclear pore complex exhibit ideal-polymer behavior, balancing repulsive and attractive interactions to enable both cohesion and dynamic transport.

Dynamic clustering regulates activity of mechanosensitive membrane channels

The paper develops a model showing that mechanosensitive channels cluster under stress, leading to inactivation and protecting the cell from cytoplasmic loss.

Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico

This paper develops a computational model to simulate ESCRT-III filament dynamics and shows how changes in filament geometry drive membrane remodeling and scission.

Iron chelation by curcumin suppress both curcumin-induced autoghagy and cell death together with iron overload neoplastic transformation

This study investigates how curcumin affects iron overload-induced autophagy, apoptosis, and tumorigenesis in liver cells.