Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma
T. Kato, R. P. Jenkins, S. Derzsi, M. Tozluoglu, A. Rullan, S. Hooper, R. A. G. Chaleil, X. Fu, H. Joyce, S. Thavaraj, P. A. Bates, E. Sahai
This study identifies factors determining collective invasion patterns in squamous cell carcinoma, showing that high cell-cell adhesion and proteolysis promote aggressive growth and invasion.
bioRxiv · Nov 24, 2021Cancer Biology