Author

S. Hooper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Sahai· 4 shared A. Rullan· 2 shared C. Swanton· 2 shared P. Chakravarty· 2 shared A. J. Narvaez· 1 shared A. M. I. Le Marois· 1 shared A. Melcher· 1 shared C. D. H. Ratcliffe· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCancer Biology

E. Sahai

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4 papers

Recent·Most cited

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

A. M. I. Le Marois, S. Bailey, S. Hooper, S. Kumar, H. Sparks, Y. Alexandrov, D. R. Caswell, F. Fröhlich, K. Schlegelmilch, K. Valand, M. J. Martin, A. J. Narvaez, C. Swanton, J. Downward, C. Dunsby, , E. Sahai

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

bioRxiv · May 14, 2024 · PreprintCancer Biology

Cancer cell - fibroblast crosstalk via HB-EGF/EGFR/MEK signalling promotes macrophage recruitment in squamous cell carcinoma

G. Giangreco, A. Rullan, Y. Naito, D. Biwas, Y.-H. Liu, S. Hooper, P. Nenclares, S. Bhide, M. Cheang, P. Chakravarty, E. Hirata, C. Swanton, A. Melcher, K. Harrington, E. Sahai

The paper identifies a gene expression signature of cancer-fibroblast crosstalk in squamous cell carcinoma and shows its prognostic relevance and role in macrophage recruitment.

bioRxiv · Jul 13, 2023 · PreprintCancer Biology

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

T. Kato, R. P. Jenkins, S. Derzsi, M. Tozluoglu, A. Rullan, S. Hooper, R. A. G. Chaleil, X. Fu, H. Joyce, S. Thavaraj, P. A. Bates, E. Sahai

This study identifies factors determining collective invasion patterns in squamous cell carcinoma, showing that high cell-cell adhesion and proteolysis promote aggressive growth and invasion.

bioRxiv · Nov 24, 2021Cancer Biology

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

M. Zangrossi, P. Chakravarty, P. Romani, C. D. H. Ratcliffe, S. Hooper, M. Dori, M. Forcato, S. Bicciato, S. Dupont, E. Sahai, M. MONTAGNER

This study identifies EphB6 as a regulator of the TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells in a foreign environment.

bioRxiv · Nov 10, 2020Cancer Biology