Author

S. Detry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:electronic health records· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

S. N. Savvides· 2 shared A. Kremer· 1 shared B. Asselbergh· 1 shared C. Gabay· 1 shared D. Clancy· 1 shared F.-J. Müller· 1 shared H. T. McMahon· 1 shared I. Kurth· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

S. N. Savvides

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2 papers

Recent·Most cited

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein (IL-18BP) in inflammation and tumor immunity

S. Detry, J. Andries, Y. Bloch, C. Gabay, D. Clancy, S. N. Savvides

This paper determines the crystal structure of the human IL-18:IL-18BP complex, revealing the molecular mechanism of IL-18 sequestration and identifying a higher-order 2:2 assembly with enhanced activity restraint.

bioRxiv · Feb 10, 2022Immunology

Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

M. Krols, S. Detry, B. Asselbergh, L. Almeida-Souza, A. Kremer, S. Lippens, R. de Rycke, V. De Winter, F.-J. Müller, I. Kurth, H. T. McMahon, S. N. Savvides, V. Timmerman, S. Janssens

This study shows that mutations in ATL3 cause aberrant ER membrane tethering, disrupting ER network organization and contributing to sensory neuropathy.

bioRxiv · Apr 5, 2018Cell Biology