Author

D. Clancy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bileck· 1 shared A. Bolado· 1 shared A. von Kriegsheim· 1 shared B. Collis· 1 shared C. Adrain· 1 shared C. Gabay· 1 shared C. Gerner· 1 shared E. Burbridge· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Bileck

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2 papers

Recent·Most cited

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein (IL-18BP) in inflammation and tumor immunity

S. Detry, J. Andries, Y. Bloch, C. Gabay, D. Clancy, S. N. Savvides

This paper determines the crystal structure of the human IL-18:IL-18BP complex, revealing the molecular mechanism of IL-18 sequestration and identifying a higher-order 2:2 assembly with enhanced activity restraint.

bioRxiv · Feb 10, 2022Immunology

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

I. Oikonomidi, E. Burbridge, M. Cavadas, G. Sullivan, D. Clancy, B. Collis, J. Brezinova, J. Humpolickova, T. Hu, A. Bileck, C. Gerner, A. Bolado, A. von Kriegsheim, K. Strisovsky, S. J. Martin, C. Adrain

This study identifies iTAP as a novel iRhom interactor that stabilizes iRhom and TACE, essential for TNF secretion, and shows its role in regulating inflammation.

bioRxiv · Jan 30, 2018Biochemistry