Author

S. E. Zanders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 6 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Approach:statistical model· 2 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

J. J. Lange· 3 shared I. M. Sabbarini· 2 shared M. A. Bravo Nunez· 2 shared M. T. Eickbush· 2 shared R. B. Billmyre· 2 shared R. L. Unckless· 2 shared S. McCroskey· 2 shared A. C. Mok· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersEvolutionary Biology

J. J. Lange

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Author profile →

6 papers

Recent·Most cited

Modeling the Evolution of Populations with Multiple Killer Meiotic Drivers

J. F. L. Hernandez, B. Y. Rubinstein, R. L. Unckless, S. E. Zanders

The paper models the evolution of two meiotic drivers in a population, showing how duplication and divergence can lead to fixation and impact synthetic gene drive design.

bioRxiv · Sep 28, 2023 · PreprintEvolutionary Biology

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M. De Carvalho, G.-S. Jia, A. Nidamangala Srinivasa, R. B. Billmyre, Y.-H. Xu, J. J. Lange, I. M. Sabbarini, L.-L. Du, S. E. Zanders

This study identifies the persistence of the wtf meiotic driver gene family across four fission yeast species diverging over 100 million years ago, showing that active meiotic drive systems can persist long-term.

bioRxiv · Jun 24, 2022Evolutionary Biology

Diverse mating phenotypes impact the spread of wtf meiotic drivers in S. pombe

S. E. Zanders, J. F. Lopez Hernandez, R. M. Helston, J. J. Lange, R. B. Billmyre, S. H. Schaffner, M. T. Eickbush, S. McCroskey

The paper examines mating phenotypes in S. pombe natural isolates to explain the prevalence of meiotic drivers despite low outcrossing rates.

bioRxiv · May 28, 2021Evolutionary Biology

Atypical meiosis can be adaptive in outcrossed S. pombe due to wtf meiotic drivers

M. A. Bravo Nunez, I. M. Sabbarini, L. E. Eide, R. L. Unckless, S. E. Zanders

The paper shows that wtf meiotic drivers in S. pombe can create a fitness landscape where atypical gametes are advantageous, reducing the cost of meiotic fidelity mutations and potentially increasing their benefit.

bioRxiv · Apr 28, 2020Evolutionary Biology

The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

N. L. Nuckolls, A. C. Mok, J. J. Lange, K. Yi, T. S. Kandola, A. M. Hunn, S. McCroskey, J. L. Snyder, M. A. Bravo Nunez, M. McClain, S. A. McKinney, C. Wood, R. Halfmann, S. E. Zanders

This study shows that the wtf4 meiotic driver uses protein aggregation and sequestration to selectively kill cells, revealing a mechanism for meiotic drive.

bioRxiv · Feb 5, 2020Cell Biology

Killer meiotic drive and dynamic evolution of the wtf gene family

M. T. Eickbush, J. M. Young, S. E. Zanders

The paper analyzes the evolution of the wtf gene family in S. pombe, showing dynamic evolution through copy number variation and recombination mechanisms involving transposons.

bioRxiv · Nov 3, 2018Evolutionary Biology