Author

R. Halfmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:proteomics· 3 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

J. J. Lange· 5 shared A. Rodriguez Gama· 3 shared J. R. Unruh· 2 shared J. Wu· 2 shared M. Cook· 2 shared S. Venkatesan· 2 shared T. Miller· 2 shared T. S. Kandola· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBiophysics

J. J. Lange

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Author profile →

5 papers

Recent·Most cited

Adaptor protein supersaturation drives innate immune signaling and cell fate

A. Rodriguez Gama, T. Miller, S. Venkatesan, J. J. Lange, J. Wu, X. Song, W. D. Bradford, M. Cook, J. R. Unruh, R. Halfmann

The paper identifies DFD adaptors as energy reservoirs through supersaturation, showing their role in innate immune signaling and cell fate decisions.

bioRxiv · Mar 20, 2023 · PreprintBiophysics

A nucleation barrier spring-loads the CBM signalosome for binary activation

A. Rodriguez Gama, T. Miller, J. J. Lange, J. Unruh, R. Halfmann

The paper investigates the CBM signalosome's binary activation mechanism, showing that BCL10's nucleation barrier stores energy for rapid NF-κB activation upon stimulation.

bioRxiv · Jan 28, 2022Cell Biology

Mechanistic inferences from analysis of measurements of protein phase transitions in live cells

A. E. Posey, K. M. Ruff, J. M. Lalmansingh, T. S. Kandola, J. J. Lange, R. Halfmann, R. V. Pappu

This paper develops a supervised method to classify phase transitions in live cells using DAmFRET data, revealing sequence features that drive prion-like behavior and enabling quantitative analysis of nucleation probabilities.

bioRxiv · Nov 4, 2020Biophysics

The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

N. L. Nuckolls, A. C. Mok, J. J. Lange, K. Yi, T. S. Kandola, A. M. Hunn, S. McCroskey, J. L. Snyder, M. A. Bravo Nunez, M. McClain, S. A. McKinney, C. Wood, R. Halfmann, S. E. Zanders

This study shows that the wtf4 meiotic driver uses protein aggregation and sequestration to selectively kill cells, revealing a mechanism for meiotic drive.

bioRxiv · Feb 5, 2020Cell Biology

Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior

T. Khan, T. Kandola, J. Wu, E. Ketter, S. Venkatesan, J. J. Lange, A. Rodriguez Gama, A. Box, J. R. Unruh, M. Cook, R. Halfmann

The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.

bioRxiv · Apr 19, 2018Biophysics