Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates
J. Pettmann, L. Awada, B. Rozycki, A. Huhn, S. Faour, M. A. Kutuzov, L. Limozin, T. R. Weikl, P. A. van der Merwe, P. Robert, O. Dushek
The paper shows mechanical forces reduce T cell antigen discrimination by accelerating off-rates of higher-affinity antigens.
bioRxiv · May 5, 2022 · PreprintImmunology