T. R. Weikl

The paper shows mechanical forces reduce T cell antigen discrimination by accelerating off-rates of higher-affinity antigens.

The paper demonstrates that cooperative stabilization of close-contact zones in T-cell adhesion is sensitive to 1-3 foreign-peptide-MHC complexes and occurs at a sharp affinity threshold, implying selectivity in T-cell recognition.

This study uses molecular dynamics simulations to analyze structural variability and motions of the TCR-CD3 complex, revealing tilt angles and coupled domain movements.