Author

A. Huhn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

M. A. Kutuzov· 3 shared O. Dushek· 3 shared P. A. van der Merwe· 3 shared D. B. Wilson· 2 shared J. Pettmann· 2 shared A. Townsend· 1 shared B. Rozycki· 1 shared C. Deane· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

M. A. Kutuzov

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

A. Huhn, D. A. Nissley, D. B. Wilson, M. A. Kutuzov, R. Donat, T. K. Tan, Y. Zhang, M. I. Barton, C. Liu, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, A. Townsend, W. S. James, G. Screaton, , O. Dushek

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

bioRxiv · Sep 6, 2023 · PreprintImmunology

Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates

J. Pettmann, L. Awada, B. Rozycki, A. Huhn, S. Faour, M. A. Kutuzov, L. Limozin, T. R. Weikl, P. A. van der Merwe, P. Robert, O. Dushek

The paper shows mechanical forces reduce T cell antigen discrimination by accelerating off-rates of higher-affinity antigens.

bioRxiv · May 5, 2022 · PreprintImmunology

The discriminatory power of the T cell receptor

J. Pettmann, A. Huhn, E. Abu-Shah, M. A. Kutuzov, D. B. Wilson, M. Dustin, S. Davis, P. A. van der Merwe, O. Dushek

This study measures TCR discriminatory power against pMHC antigens and finds it is imperfect, with T cells responding to low-affinity self pMHC with KD ~1 mM.

bioRxiv · Nov 16, 2020Immunology