Caspase-2 protects against ferroptotic cell death
S. Dawar, M. C. Benitez, Y. Lim, T. A. Dite, J. M. Yousef, N. Thio, S. Garciaz, T. D. Jackson, J. V. Milne, L. F. Dagley, W. A. Phillips, S. Kumar, N. J. Clemons
This study shows caspase-2 protects mutant-p53 cancer cells from ferroptotic death by non-proteolytically interacting with proteins to limit GPX4 degradation.
bioRxiv · Aug 22, 2023Cancer Biology