Author

Y. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 3 Cancer Biology· 2 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:cell signaling & trafficking· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3 Organism:mouse· 3

Frequent Co-Authors

D. Wirtz· 2 shared E. A. Hanna· 2 shared P. R. Nair· 2 shared S. Kumar· 2 shared W. Du· 2 shared Z. Wan· 2 shared A. C. Johnston· 1 shared A. Forjaz· 1 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

D. Wirtz

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

A. J. Crawford, A. Johnston, W. Du, E. A. Hanna, D. Schell, Z. Wan, T.-H. Chen, F. Wu, K. Ren, Y. Lim, P. R. Nair, D. Wirtz

This paper introduces a 3D in vitro assay to study immune cell infiltration and cytotoxicity in solid tumors, showing it captures key steps of immune cell interaction with the tumor microenvironment.

bioRxiv · Mar 27, 2024 · PreprintCancer Biology

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

A. C. Johnston, G. M. Alicea, C. C. Lee, P. V. Patel, E. A. Hanna, E. Vaz, A. Forjaz, Z. Wan, P. R. Nair, Y. Lim, T. Chen, W. Du, D. Kim, T. D. Nichakawade, V. W. Rebecca, , D. Wirtz

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.

bioRxiv · Dec 13, 2023 · PreprintImmunology

Caspase-2 protects against ferroptotic cell death

S. Dawar, M. C. Benitez, Y. Lim, T. A. Dite, J. M. Yousef, N. Thio, S. Garciaz, T. D. Jackson, J. V. Milne, L. F. Dagley, W. A. Phillips, S. Kumar, N. J. Clemons

This study shows caspase-2 protects mutant-p53 cancer cells from ferroptotic death by non-proteolytically interacting with proteins to limit GPX4 degradation.

bioRxiv · Aug 22, 2023Cancer Biology

Renal tubular function and morphology revealed in kidney without labeling using three-dimensional dynamic optical coherence tomography

P. Mukherjee, S. Fukuda, D. Lukmanto, T. H. Tran, K. Okada, S. Makita, I. A. El-Sadek, Y. Lim, Y. Yasuno

This study uses 3D dynamic OCT to image renal tubule function and morphology in normal and obstructed mouse kidneys without labeling.

bioRxiv · May 1, 2023Bioengineering

Cultivation of SAR202 Bacteria from the Ocean

Y. Lim, J.-H. Seo, S. J. Giovannoni, I. Kang, J.-C. Cho

This study successfully cultivates SAR202 bacteria, revealing their slow growth, light inhibition, and metabolic capabilities involving multiple catabolic pathways.

bioRxiv · Mar 25, 2023Microbiology

Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery

Y. Zhang, X. Wu, R. A. Vadlamani, Y. Lim, J. Kim, K. David, E. Gilbert, Y. Li, R. Wang, S. Jiang, A. Wang, H. Sontheimer, D. English, S. Emori, R. V. Davalos, , X. Jia

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

bioRxiv · Jan 27, 2023 · PreprintBioengineering

Q-SHINE: a versatile sensor for glutamine measurement via ligand-induced dimerization

M.-H. Seo, Y. Lim, J. Y. Kim, Y. H. Jung, J. H. Lee, M. S. Baek, J. H. Jung, H.-Y. Kim, W. Lee, K. Park

The paper introduces Q-SHINE, a sensor for measuring glutamine levels through ligand-induced dimerization, enabling accurate detection in bio-fluids and living cells.

bioRxiv · Jun 28, 2022Bioengineering

G protein-coupled receptor signaling regulates ER-mitochondria contacts

Y. Lim, I.-T. Cho, H. G. Rennke, G. Cho

This study identifies GPCR agonists that promote ER-mitochondria contacts through chemical screening and orthogonal assays.

bioRxiv · May 11, 2020 · PreprintCell Biology

Phosphorylation by Aurora B kinase regulates caspase-2 activity and function

S. Kumar, Y. Lim, D. De Bellis, J. J. Sandow, L. Capalbo, P. P. D'Avino, J. M. Murphy, A. I. Webb, L. Dorstyn

This study identifies Aurora B kinase-mediated phosphorylation of caspase-2 at S384, which inhibits its catalytic activity and apoptosis function during mitotic catastrophe.

bioRxiv · Mar 5, 2020Cell Biology

Mechanically Resolved Imaging of Bacteria using Expansion Microscopy

Y. Lim, M. Khariton, K. M. Lane, A. L. Shiver, K. M. Ng, S. R. Bray, J. Qin, K. C. Huang, B. Wang

This paper introduces expansion microscopy to distinguish bacterial species and detect phenotypic changes in dense microbial communities.

bioRxiv · Apr 29, 2019Biophysics

Cardioprotection by the mitochondrial unfolded protein response (UPRmt) is mediated by activating transcription factor 5 (ATF5)

Y. T. Wang, Y. Lim, M. N. McCall, C. M. Haynes, K. W. Nehrke, P. S. Brookes

This study shows that ATF5 is required for cardioprotection induced by UPRmt activators against ischemia-reperfusion injury.

bioRxiv · Nov 9, 2018Cell Biology

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

D. Kuppers, S. Arora, Y. Lim, A. Lim, L. Carter, P. Corrin, C. Plasier, R. Basom, J. Delrow, S. Wang, H. He, B. Torok-Storb, A. Hsieh, P. Paddison

The paper identifies m6A mRNA methylation as a regulator of erythropoiesis by promoting the translation of key genes involved in erythroid lineage specification.

bioRxiv · Oct 31, 2018Cell Biology