Somatic Mutations in Clonally Expanded T-lymphocytes in Patients with Chronic Graft-Versus-Host Disease
G. Park, S. Mustjoki, D. Kim, J. Huuhtanen, S. Lundgren, R. K. Khajuria, A. M. Hurtado, C. Munoz-Calleja, L. Cardenoso, V. Gomez-Garcia de Soria, T. H. Chen-Liang, S. Eldfors, P. Ellonen, S. Hannula, O. Bruck, , M. A. I. Keranen
This study identifies somatic mutations in clonally expanded T-cells in chronic GvHD patients, showing they drive persistent activation and resistance to mTOR inhibitors.
bioRxiv · Aug 31, 2019 · PreprintImmunology