S. Mustjoki

Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma

This study evaluates small molecule STAT3/5 inhibitors for treating AML and NKCL, showing growth arrest and synergy with existing therapies in vitro and in vivo.

Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

This paper uses single-cell multi-omics to analyze CML patient data, showing that cellular heterogeneity correlates with therapy response and identifies markers for LSCs and HSCs.

EPIC-TRACE: predicting TCR binding to unseen epitopes using attention and contextualized embeddings

EPIC-TRACE predicts TCR binding to unseen epitopes using attention mechanisms and contextualized embeddings, outperforming existing models.

Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment

The paper uses a patient-derived explant model to show metformin enhances dendritic cell maturation by inhibiting complex I, improving anti-tumor immunity when combined with venetoclax.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

Single-cell functional genomics of natural killer cell evasion in blood cancers

The paper uses single-cell and genome-scale functional genomics to study how blood cancer cells evade NK cells, identifying key genes and pathways involved in resistance and sensitivity.

Integrative Analysis of Histological Textures and Lymphocyte Infiltration in Renal Cell Carcinoma using Deep Learning

This study uses deep learning to analyze histological textures and lymphocyte infiltration in renal cell carcinoma, finding associations between tissue features and clinical outcomes.

Tracing back primed resistance in cancer via sister cells

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.

Somatic Mutations in Clonally Expanded T-lymphocytes in Patients with Chronic Graft-Versus-Host Disease

This study identifies somatic mutations in clonally expanded T-cells in chronic GvHD patients, showing they drive persistent activation and resistance to mTOR inhibitors.

Immunogenomic landscape of hematological malignancies

This study links immunological features to cancer subtypes, genetic alterations, and patient survival in hematological malignancies using integrated genomic and transcriptomic data.

Characterization of novel TMEM173 mutation with additive IFIH1 risk allele

The paper reports a novel gain-of-function TMEM173 mutation and its additive effects with IFIH1 risk allele on clinical phenotype in a multigeneration family.