Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells
A. J. Earle, T. J. Kirby, G. R. Fedorchak, P. Isermann, J. Patel, S. Iruvanti, S. A. Moore, G. Bonne, L. L. Wallrath, J. Lammerding
This study shows that LMNA mutations cause nuclear envelope rupture and DNA damage in muscle cells, leading to disease through mechanical stress and DNA damage pathways.
bioRxiv · Aug 17, 2019Cell Biology