Author

P. Isermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. Lammerding· 4 shared P. Davidson· 2 shared A. J. Earle· 1 shared A. L. McGregor· 1 shared A. Matzvamuse· 1 shared A.-A. Varlet· 1 shared D. Aubry· 1 shared D. Kim· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCell Biology

J. Lammerding

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

E. S. Bell, P. Shah, N. Zuela - Sopilniak, D. Kim, A.-A. Varlet, J. L. P. Morival, A. L. McGregor, P. Isermann, P. Davidson, J. J. Elacqua, J. Lakins, L. Vahdat, V. Weaver, M. B. Smolka, P. Span, J. Lammerding

This study shows that low lamin A levels in breast cancer cells increase nuclear deformability and metastatic capacity, with lower lamin A levels linked to poorer disease-free survival in human tumors.

Oncogene · Jul 27, 2022Peer-reviewedCancer Biology

Lamin B2 follows lamin A/C- mediated nuclear mechanics and cancer cell invasion efficacy

M. Vortmeyer-Krause, M. te Lindert, J. te Riet, V. t. te Boekhorst, R. Marke, R. Perera, P. Isermann, T. van Oorschot, M. Zwerger, F. Yang, M. Svoren, A. Matzvamuse, J. Lammerding, P. Friedl, K. Wolf

The paper investigates the role of lamin B2 in nuclear mechanics and cancer cell invasion, finding that lamin B2 cooperates with lamin A/C to regulate nuclear deformability and migration efficacy.

bioRxiv · Apr 7, 2020 · PreprintCell Biology

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

A. J. Earle, T. J. Kirby, G. R. Fedorchak, P. Isermann, J. Patel, S. Iruvanti, S. A. Moore, G. Bonne, L. L. Wallrath, J. Lammerding

This study shows that LMNA mutations cause nuclear envelope rupture and DNA damage in muscle cells, leading to disease through mechanical stress and DNA damage pathways.

bioRxiv · Aug 17, 2019Cell Biology

High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells

P. Davidson, G. Fedorchak, S. Mondesert-Deveraux, E. Bell, P. Isermann, D. Aubry, R. Allena, J. Lammerding

This paper introduces a microfluidic device for high-throughput measurement of time-dependent nuclear mechanics in cells, showing that lamin A/C loss increases nuclear deformability.

bioRxiv · May 20, 2019Biophysics