Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines
S. Prithiviraj, A. Garcia Garcia, K. Linderfalk, B. Yiguang, S. Ferveur, L. N. Falck, A. Subramaniam, S. Mohlin, D. H. Gil, S. J. Dupard, D. Zacharaki, D. B. Raina, P. E. Bourgine
This study uses CRISPR/Cas9 to edit human mesenchymal stem cells to produce engineered extracellular matrices with modified VEGF and RUNX2 expression, showing altered osteogenic properties.
bioRxiv · Jul 28, 2023Bioengineering