E. Gordon

'Target-and-release' nanoparticles for effective immunotherapy of metastatic ovarian cancer

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.

Endothelial c-Src mediates neovascular tuft formation in Oxygen-Induced Retinopathy

This study shows that c-Src is essential for neovascular tuft formation in Oxygen-Induced Retinopathy, as its depletion reduces tuft formation without affecting cell death, proliferation, or adhesion.

Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering

This paper improves prime editing by modulating DNA repair pathways and engineering pegRNA, achieving higher precision and efficiency in human and mouse cells.

c-Src induced vascular malformations require localised matrix degradation at focal adhesions

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

Comparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic DNMT1/3b double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway

The paper compares N-glycoproteomes of HCT116 cancer cells and DKO1 non-tumorigenic cells, revealing hyper-M6P modification and its potential role in cancer biology.

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

SARS-CoV-2 Spike Protein Regulation of Angiotensin Converting Enzyme 2 and Tissue Renin-Angiotensin Systems: Influence of Biologic Sex

This study examines how SARS-CoV-2 Spike protein affects ACE2 and RAS in lung and adipose tissues of male and female mice, revealing sex-specific differences in ACE2 expression and RAS activity.

An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

The paper explains how E-cadherin-actin interactions mediate mechanical signals from cortical flows to inhibit epithelial cell migration based on contact orientation.

Tissue-Specific Biochemical Differences Between Chronic Wasting Disease Prions Isolated From Free Ranging, White-Tailed Deer (Odocoileus virginianus)

This study compares biochemical differences between prions isolated from the brain and lymph node of white-tailed deer with chronic wasting disease.

Multiple known and a novel parvovirus associated with an outbreak of feline diarrhea and vomiting

The paper identifies a novel chapparvovirus, fechavirus, associated with an outbreak of feline diarrhea and vomiting, alongside other viral pathogens.