Author

S. J. Pellock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

D. Baker· 3 shared A. Kang· 2 shared I. Anishchenko· 2 shared J. Dauparas· 2 shared A. Bera· 1 shared A. H.-W. Yeh· 1 shared A. K. Bera· 1 shared B. Coventry· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

D. Baker

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3 papers

Recent·Most cited

Small-molecule binding and sensing with a designed protein family

G. R. Lee, S. J. Pellock, C. Norn, D. Tischer, J. Dauparas, I. Anishchenko, J. A. M. Mercer, A. Kang, A. Bera, H. Nguyen, I. Goreshnik, D. Vafeados, N. Roullier, H. L. Han, B. Coventry, , D. Baker

This paper designs a protein family that binds and senses small molecules using deep learning and physics-based methods, achieving nanomolar sensitivity for cortisol.

bioRxiv · Nov 1, 2023Biochemistry

Improving protein expression, stability, and function with ProteinMPNN

K. H. Sumida, R. Nunez Franco, I. Kalvet, S. J. Pellock, B. I. M. Wicky, L. F. Milles, J. Dauparas, J. Wang, Y. Kipnis, N. Jameson, A. Kang, J. De La Cruz, B. Sankaran, A. K. Bera, G. Jimenez Oses, D. Baker

This paper introduces ProteinMPNN, a deep learning model that improves protein expression, stability, and function by incorporating evolutionary and structural information.

bioRxiv · Oct 3, 2023Biochemistry

De novo protein design by deep network hallucination

I. Anishchenko, T. M. Chidyausiku, S. Ovchinnikov, S. J. Pellock, D. Baker

The paper uses deep networks to design new proteins by inverting structure prediction models, resulting in 27 stable folded proteins with diverse structures.

bioRxiv · Jul 22, 2020Bioengineering