H. Nguyen

This study characterizes the glycosylation of surface proteins in E. coli, focusing on type I fimbriae and flagella, revealing chemically resistant glycans and unexpected glycan structures.

This study shows GBM cells use Plexin-B2 to regulate membrane tension and mechano-electrical coupling for migration through confined spaces.

This study shows that B cell pyruvate oxidation supports antigen-specific activation, driving inflammation and fibrosis in MASH.

This paper designs a protein family that binds and senses small molecules using deep learning and physics-based methods, achieving nanomolar sensitivity for cortisol.

This study finds no difference in taste and smell intensity or liking between young people with and without a history of COVID-19.

The paper develops a computational model to study ion-DNA interactions and shows it accurately predicts experimental results without parameter tuning.

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.

This study evaluates the effectiveness of thiazolidinediones (TZDs) as bitter blockers by testing their ability to reduce bitterness of TAF and PRAZ in two taste panels.

This study benchmarks ProteinMPNN against Rosetta in designing two-component protein nanomaterials, showing comparable success with significantly reduced computation and no manual refinement.

This study shows that 5-ASA can replace Clostridia to prevent Candida albicans overgrowth by restoring epithelial hypoxia after antibiotic treatment.

The paper uses molecular dynamics simulations to show that SARS-CoV-2 NSP1 increases mRNA binding to 40S ribosomes, inhibiting translation by stabilizing the complex through electrostatic interactions and water molecules.

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

This study investigates the impact of a Mediterranean diet on the gut microbiome and inflammation in MPN patients, finding stable microbiome composition but associations between bacterial taxa and cytokine levels.

This paper designs ice-binding proteins with controlled under-twisting of alpha-helices to enhance ice recrystallization inhibition.

This study examines how gut microbiome composition and changes in response to cocaine affect behavioral sensitization in two divergent Collaborative Cross mouse strains.

The paper designs extendable protein multiplexes with symmetric architectures to create precisely patterned nanofibers through controlled repeat propagation and hydrophilic patch placement.

This study develops a bioengineered FZD4-selective WNT surrogate that improves BBB function and reduces ischemic stroke damage in mice.

Deep network-based protein design generates symmetric homo-oligomers with high structural accuracy, demonstrating the potential for creating novel nanomachines and biomaterials.

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

The paper identifies and characterizes unannotated proteins in green lineage species, finding many with novel structures and potential plastid functions.

The paper investigates online trade in jaguar parts across multiple languages and platforms, identifying 230 posts and 125 jaguar parts, with teeth being the most common item.

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

A deep learning method for protein sequence design shows high performance in both simulations and experiments, applicable to various design challenges.

The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.

This study compares the phenotypes of two Chlamydomonas reinhardtii strains, CC-1690 and CC-5325, revealing differences in growth, photosynthesis, cell wall, and circadian rhythms.

This paper develops a method to create cell-laden macroporous hydrogels using dissolvable microgels, enabling controlled cell assembly and secretion of growth factors.

This study investigates how metabolic dysregulation during severe SARS-CoV-2 infection impairs lymphocyte memory formation through hypoxia-induced metabolic shifts and cellular exhaustion.

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

The paper investigates two CLas effectors, P235 and Effector 3, showing they suppress citrus innate immune responses and contribute to HLB pathogenesis by inhibiting immune proteins and inducing cell death.