Inhibition of pyrimidine synthesis in murine skin wounds induces a pyoderma gangrenosum-like neutrophilic dermatosis accompanied by spontaneous gut inflammation
S. Jatana, A. K. Ponti, E. E. Johnson, N. A. Rebert, J. L. Smith, C. G. Fulmer, E. V. Maytin, J.-P. Achkar, A. P. Fernandez, C. McDonald
This study develops a murine model of pyoderma gangrenosum with concurrent gut inflammation by inhibiting pyrimidine synthesis in skin wounds.
bioRxiv · Dec 20, 2022Immunology