Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in Enterococcus faecalis
R. A. G. da Silva, J. J. Wong, H. Antypas, P. Y. Choo, K. Goh, S. Jolly, C. Liang, L. T. K. Sing, M. Veleba, G. Hu, J. Chen, K. A. Kline
Mitoxantrone synergizes with vancomycin against vancomycin-resistant Enterococcus faecalis by direct antibiotic activity and enhancing host macrophage recruitment and bactericidal activity.
bioRxiv · Oct 24, 2022 · PreprintMicrobiology