C. Liang

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries

This study uses live-cell single-molecule tracking in yeast to analyze the dynamics of RNA polymerase machineries, revealing new insights into transcriptional processes and the role of the CTD in splicing.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy

Voluntary wheel running improves muscle function and reduces tubular aggregates in a mouse model of tubular aggregate myopathy.

Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells

This paper identifies FOL-026, an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells, mimicking VEGF effects and showing potential for vascular repair.

Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets

The paper shows that the disordered C-terminal domain of RNAPII confines its diffusion to a subnuclear region, enhancing target search efficiency in yeast.

Anthracyclines inhibit SARS-CoV-2 infection

This study identifies anthracyclines as potential SARS-CoV-2 inhibitors through a microbial metabolite screening effort, showing they inhibit viral infection via different mechanisms.

Biomimetic human lung alveolar interstitium chip with extended longevity

This paper develops a biomimetic human lung alveolar interstitium chip that improves epithelial barrier function and extends longevity beyond eight weeks.

Tissue- and sex-specific DNA damage tracks aging in rodents and humans

This study identifies DNA damage patterns across tissues and sexes in rodents and humans, revealing age- and sex-dependent variations in DNA adducts and their potential as disease markers.

Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in Enterococcus faecalis

Mitoxantrone synergizes with vancomycin against vancomycin-resistant Enterococcus faecalis by direct antibiotic activity and enhancing host macrophage recruitment and bactericidal activity.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

Molecular and genetic mechanisms conferring dissolution of dioecy in Diospyros oleifera Cheng

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

SARS-CoV-2 accessory protein ORF8 decreases antibody-dependent cellular cytotoxicity

This study shows that SARS-CoV-2 accessory protein ORF8 reduces antibody-dependent cellular cytotoxicity by binding CD16a and decreasing CD16 surface levels on monocytes and NK cells.

The Myb family genes in the rice pathogen Magnaporthe oryzae: Finding and deleting more family members involved in pathogenicity

The paper identifies and deletes 19 Myb genes in Magnaporthe oryzae, finds most are expressed during infection, and identifies co-regulated groups with potential roles in pathogenicity.

Dominant species determine ecosystem stability across scales in Inner Mongolian grassland

The paper examines how dominant species influence ecosystem stability across different spatial scales in Inner Mongolian grassland, finding that stability is linked to dominant species dynamics and precipitation patterns.

Mechanisms of ventricular arrhythmias elicited by coexistence of multiple electrophysiological remodeling in ischemia: a simulation study

This study simulates reentrant arrhythmias in ischemic hearts with multiple electrophysiological remodelling stages, showing that spatial heterogeneity of refractory periods and excitation threshold differences drive reentry depending on border orientation relative to wavefronts.

All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system

This paper introduces an integrated system for automated multi-functional imaging and analysis to study YAP mechanosensitivity in human cells.

Integrated Multi-Omics Data Reveals the Molecular Subtypes of Prostate Cancer

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

Multi-omics consensus ensemble refines the classification of muscle-invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

A Phylogenetic Independent Contrast Method under the Ornstein-Uhlenbeck Model and its Applications in Correlated Evolution

This paper introduces OU-PIC, an extension of Felsenstein's PIC method under the Ornstein-Uhlenbeck model, showing improved statistical performance in detecting correlated trait evolution.

Low-disturbance Farming Regenerates Healthy Deep Soil towards Sustainable Agriculture

This study shows that low-disturbance farming practices improve deep soil health, microbial diversity, and crop yield over ten years, supporting sustainable agriculture.

IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

Prime-boost vaccination of mice and Rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

Tumor Immunity Microenvironment-based classifications of bladder cancer for enhancing cancer immunotherapy

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.