ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms
A. J. Arribas, S. Napoli, L. Cascione, L. Barnabei, G. Sartori, E. Cannas, E. Gaudio, C. Tarantelli, A. A. Mensah, F. Spriano, A. Zucchetto, F. M. Rossi, A. Rinaldi, M. Castro de Moura, S. Jovic, , F. Bertoni
This study identifies ERBB4-mediated signaling as a mechanism of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms and shows that targeting ERBB signaling can restore sensitivity.
bioRxiv · Jan 1, 2023Cancer Biology