Author

F. Mele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:CITE-seq· 1

Frequent Co-Authors

D. Jarrossay· 3 shared A. Cassotta· 2 shared A. Ceschi· 2 shared A. Lanzavecchia· 2 shared C. Garzoni· 2 shared F. Sallusto· 2 shared J. S. Low· 2 shared M. Foglierini· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

D. Jarrossay

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

J. S. Low, J. Jerak, M. A. Tortorici, M. McCallum, D. Pinto, A. Cassotta, M. Foglierini, F. Mele, R. Abdelnabi, B. Weynand, J. Noack, M. Montiel-Ruiz, S. Bianchi, F. Benigni, N. Sprugasci, , F. Sallusto

The paper identifies monoclonal antibodies that neutralize multiple coronaviruses by targeting the fusion peptide, which becomes exposed upon ACE2 engagement.

bioRxiv · Mar 30, 2022Immunology

Clonal dissection of immunodominance and cross-reactivity of the CD4+ T cell response to SARS-CoV-2

J. S. Low, D. Vaqueirinho, F. Mele, M. Foglierini, M. Perotti, D. Jarrossay, S. Jovic, T. Terrot, A. Franzetti Pellanda, M. Biggiogero, C. Garzoni, P. Ferrari, A. Ceschi, A. Lanzavecchia, A. Cassotta, F. Sallusto

The paper identifies immunodominant and cross-reactive CD4+ T cell epitopes in SARS-CoV-2, showing their recognition in 93% of patients and potential for vaccine design.

bioRxiv · Mar 23, 2021Immunology

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

R. Yang, F. Mele, L. Worley, D. Langlais, J. Rosain, I. Benhsaien, H. Elarabi, C. A. Croft, J.-M. Doisne, P. Zhang, M. Weisshaar, D. Jarrossay, D. Latorre, Y. Shen, J. Han, , L. H Glimcher

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

bioRxiv · Aug 31, 2020Immunology